Pre-implantation Genetic Testing (PGT) has revolutionized IVF success rates. This advanced screening technology allows us to identify the healthiest embryos before transfer, significantly improving outcomes.
What is PGT?
PGT is a sophisticated laboratory technique that analyzes the genetic makeup of embryos created through IVF. There are three main types:
• PGT-A: Screens for chromosomal abnormalities (most common)
• PGT-M: Tests for specific genetic mutations
• PGT-SR: Detects structural rearrangements in chromosomes
How PGT Works
The process involves several steps:
1. Embryos develop in the laboratory for 5-7 days to the blastocyst stage
2. A few cells are carefully removed from each embryo
3. Cells are analyzed for genetic abnormalities
4. Only chromosomally normal embryos are selected for transfer
Benefits of PGT
For surrogacy programs, PGT offers significant advantages:
• Higher implantation rates: Healthy embryos are more likely to implant
• Lower miscarriage rates: Chromosomally normal embryos have lower loss rates
• Fewer transfers needed: Success is more likely on the first attempt
• Reduced multiple pregnancy risk: Allows confident single embryo transfer
Success Rate Impact
Studies show PGT can improve success rates significantly:
• Without PGT: ~40% implantation rate per transfer
• With PGT: ~70% implantation rate per transfer
• 50% reduction in miscarriage rates
Who Should Consider PGT?
PGT is particularly beneficial for:
• Women over 35 using their own eggs
• Couples with a history of miscarriage
• Those with previous IVF failures
• Anyone wanting to maximize success per transfer
The Lumina Approach
At Lumina Family, we include PGT-A testing as standard in our programs:
• All embryos are tested before transfer
• Results are reviewed with our medical team
• Only euploid (normal) embryos are transferred
• Detailed genetic counseling is provided
Understanding Results
PGT results categorize embryos as:
• Euploid: Normal chromosome count (preferred for transfer)
• Aneuploid: Abnormal chromosome count (not transferred)
• Mosaic: Mixed results (case-by-case consideration)
Cost Considerations
While PGT adds to initial costs, it often reduces overall expenses:
• Fewer transfer attempts needed
• Reduced time to successful pregnancy
• Lower emotional toll of failed cycles
Questions for Your Doctor
• Is PGT recommended for my situation?
• What type of PGT is most appropriate?
• How many embryos typically reach testing?
• What happens if all embryos are aneuploid?
Our medical team is available to discuss whether PGT is right for your journey.